| | Day | Time | | Opponent | Score | | Record | |
| February |
| | 6 | 1:00PM | vs. | Sul Ross State University | W-4-3 | | 1-0 |
| | | Game 2 | vs. | Sul Ross State University | W-9-2 | | 2-0 |
| | 9 | 1:00PM | vs. | Lubbock Christian University | RAIN | | | |
| | Rescheduled due to Wx forecast to 4/11/2010 |
| | | Game 2 | vs. | Lubbock Christian University | RAIN | | | |
| | Rescheduled due to WX forecast to 4/11/2010 |
| * | 12 | 2:00PM | @ | Huston-Tillotson | RAIN | | | |
| | Cnx due to WX - Rescheduled for 2/14/2010 |
| * | | Game 2 | @ | Huston-Tillotson | RAIN | | | |
| | Cnx due to WX - Rescheduled for 2/14/2010 |
| * | 13 | 11:00AM | @ | Our Lady of the Lake | L-2-3 | | 2-1 0-1 |
| * | | Game 2 | @ | Our Lady of the Lake | L-0-7 | | 2-2 0-2 |
| * | 14 | 11:00AM | @ | Huston-Tillotson | W-13-0 (5) | | 3-2 1-2 |
| | Make up doubleheader from 2/12/2010 |
| * | | Game 2 | @ | Huston-Tillotson | W-9-6 | | 4-2 2-2 |
| | Make up doubleheader from 2/12/2010 |
| | 19 | 1:00PM | @ | University of Texas of the Permian Basin | L-0-2 | | 4-3 |
| | | Game 2 | @ | University of Texas of the Permian Basin | L-9-16 | | 4-4 |
| * | 20 | 12:00PM | vs. | Texas College | W-16-0 (5) | | 5-4 3-2 |
| * | | Game 2 | vs. | Texas College | W-19-1 (5) | | 6-4 4-2 |
| * | 27 | 1:00PM | vs. | Bacone | L-0-6 (8) | | 6-5 4-3 |
| * | | Game 2 | vs. | Bacone | W-5-4 (9) | | 7-5 5-3 |
| | 28 | 1:00PM | vs. | University of Texas of the Permian Basin | RAIN | | | |
| | Rescheduled for 3/14/2010 |
| | | Game 2 | vs. | University of Texas of the Permian Basin | RAIN | | | |
| | Rescheduled for 3/14/2010 |
| March |
| * | 5 | 12:00PM | vs. | Texas Wesleyan | L-5-6 (8) | | 7-6 5-4 |
| * | | Game 2 | vs. | Texas Wesleyan | W-2-1 | | 8-6 6-4 |
| * | 6 | 1:00PM | vs. | Langston | W-8-0 (5) | | 9-6 7-4 |
| * | | Game 2 | vs. | Langston | W-14-1 (5) | | 10-6 8-4 |
| | 10 | 1:00PM | @ | Lubbock Christian University | L-0-12 (5) | | 10-7 |
| | | Game 2 | @ | Lubbock Christian University | L-0-11 (5) | | 10-8 |
| * | 13 | 1:00PM | vs. | Huston-Tillotson | W-5-0 | | 11-8 9-4 |
| * | | Game 2 | vs. | Huston-Tillotson | W-8-0 (6) | | 12-8 10-4 |
| | 16 | 2:00PM | vs. | University of Texas of the Permian Basin | L-1-9 (6) | | 12-9 |
| | Make up from 2/28/2010 |
| | | Game 2 | vs. | University of Texas of the Permian Basin | L-3-13 (6) | | 12-10 |
| | Make up from 2/28/2010 |
| * | 21 | 12:00PM | vs. | Northwood | L-0-13 (5) | | 12-11 10-5 |
| * | | Game 2 | vs. | Northwood | L-1-9 | | 12-12 10-6 |
| April |
| * | 2 | 12:00PM | @ | Langston | RAIN | | | |
| * | | Game 2 | @ | Langston | RAIN | | | |
| * | 3 | 1:00PM | @ | Bacone | L-1-9 (5) | | 12-13 10-7 |
| * | | Game 2 | @ | Bacone | L-0-1 | | 12-14 10-8 |
| * | 5 | 11:00AM | @ | Texas College | W-8-0 (5) | | 13-14 11-8 |
| * | | Game 2 | @ | Texas College | W-10-2 (6) | | 14-14 12-8 |
| | 12 | 3:00PM | vs. | Lubbock Christian University | L-0-9 (5) | | 14-15 |
| | Makeup doubleheader from 4/11/2010. |
| | | Game 2 | vs. | Lubbock Christian University | L-2-12 (6) | | 14-16 |
| | Makeup doubleheader from 4/11/2010. |
| | 13 | 1:00PM | @ | Sul Ross State University | W-5-3 (8) | | 15-16 |
| | | Game 2 | @ | Sul Ross State University | L-2-5 | | 15-17 |
| * | 18 | 12:00PM | vs. | Our Lady of the Lake | L-3-5 | | 15-18 12-9 |
| * | | Game 2 | vs. | Our Lady of the Lake | L-6-11 | | 15-19 12-10 |
| * | 23 | 1:00PM | @ | Northwood | L-2-7 | | 15-20 12-11 |
| * | | Game 2 | @ | Northwood | W-4-0 | | 16-20 13-11 |
| * | 24 | 12:00PM | @ | Texas Wesleyan | L-0-6 | | 16-21 13-12 |
| * | | Game 2 | @ | Texas Wesleyan | L-0-6 | | 16-22 13-13 |
| | 30 | 10:00AM | vs. | Bacone | L-1-4 | | 16-23 |
| | RRAC Tournament |
| | | 2:00PM | vs. | Huston-Tillotson | W-9-3 | | 17-23 |
| | RRAC Softball Championship |
| May |
| | 1 | 10:00AM | vs. | Our Lady of the Lake | L-2-4 | | 17-24 |
| | RRAC Softball Championship |