| | Day | Time | | Opponent | Score | | Record | |
| October |
| | 30 | 6:00PM | vs. | Philander Smith College | W-116-63 | | 1-0 |
| November |
| | 5 | 3:00PM | vs. | Faulkner University | W-75-67 | | 2-0 |
| | 6 | 1:00PM | @ | Auburn University Montgomery | W-87-73 | | 3-0 |
| | 13 | 3:30PM | @ | Oklahoma Baptist University | W-81-80 | | 4-0 |
| | 23 | 7:00PM | @ | University of Texas-Tyler | W-79-66 | | 5-0 |
| | 27 | 4:00PM | vs. | Oklahoma Baptist University | W-87-75 | | 6-0 |
| December |
| * | 2 | 7:30PM | @ | Paul Quinn | W-68-56 | | 7-0 1-0 |
| * | 4 | 7:30PM | @ | SW Assemblies of God | W-94-70 | | 8-0 2-0 |
| * | 14 | 7:30PM | @ | Bacone | W-92-64 | | 9-0 3-0 |
| * | 16 | 7:30PM | @ | Langston | W-108-82 | | 10-0 4-0 |
| | 30 | 7:00PM | vs. | University of Texas-Dallas | W-80-65 | | 11-0 |
| January |
| % | 4 | 7:45PM | @ | Northwestern State University | W-86-83 | | |
| | Exhibition Game |
| * | 6 | 7:30PM | vs. | Wiley | W-108-82 | | 12-0 5-0 |
| * | 8 | 4:00PM | vs. | Southwest | W-119-86 | | 13-0 6-0 |
| * | 10 | 7:30PM | vs. | Texas Wesleyan | W-74-68 | | 14-0 7-0 |
| * | 15 | 7:30PM | vs. | Jarvis Christian | W-101-76 | | 15-0 8-0 |
| | LSUS ranked no. 1 in the NAIA |
| * | 17 | 7:30PM | vs. | Texas College | W-106-72 | | 16-0 9-0 |
| * | 22 | 4:00PM | @ | Our Lady of the Lake | L-91-94 | | 16-1 9-1 |
| | /d/2010-2011/MensBB/OLLUvsLSUM1-22-11.pdf |
| * | 24 | 7:30PM | @ | Huston-Tillotson | W-97-87 | | 17-1 10-1 |
| * | 29 | 7:30PM | vs. | Bacone | W-88-56 | | 18-1 11-1 |
| * | 31 | 7:30PM | vs. | Langston | W-117-86 | | 19-1 12-1 |
| February |
| * | 3 | 7:30PM | @ | Wiley | W-75-73 | | 20-1 13-1 |
| * | 5 | 7:30PM | vs. | Paul Quinn | W-86-49 | | 21-1 14-1 |
| * | 7 | 7:30PM | vs. | SW Assemblies of God | W-112-88 | | 22-1 15-1 |
| * | 12 | 4:00PM | @ | Southwest | W-91-62 | | 23-1 16-1 |
| * | 14 | 7:30PM | @ | Texas Wesleyan | L-66-77 (OT) | | 23-2 16-2 |
| * | 19 | 7:30PM | @ | Jarvis Christian | L-98-99 | | 23-3 16-3 |
| * | 21 | 7:30PM | @ | Texas College | W-83-81 (2OT) | | 24-3 17-3 |
| * | 26 | 4:00PM | vs. | Our Lady of the Lake | W-87-76 | | 25-3 18-3 |
| * | 28 | 7:30PM | vs. | Huston-Tillotson | W-100-65 | | 26-3 19-3 |
| March |
| | 3 | 6:00PM | vs. | Jarvis Christian | W-80-63 | | 27-3 |
| | RRAC Men's Basketball Tournament - Quarterfinals |
| | 4 | 8:00PM | vs. | Our Lady of the Lake | W-86-75 | | 28-3 |
| | RRAC Semifinals Match in Waxahachie, Texas |
| | 5 | 6:00PM | vs. | Texas Wesleyan | W-71-67 | | 29-3 |
| | RRAC Championship Game |
| | 17 | 8:00PM | vs. | Life University | W-106-80 | | 30-3 |
| | Buffalo Funds NAIA National Tournament in Kansas City, MO. |
| | 18 | 9:45PM | vs. | Biola University | L-70-71 | | 30-4 |
| | Buffalo Funds NAIA National Tournament in Kansas City, Mo. (Sweet 16) |